Reward Processing in Health and Parkinson’s Disease: Neural Organization and Reorganization
Identifieur interne : 001581 ( Main/Exploration ); précédent : 001580; suivant : 001582Reward Processing in Health and Parkinson’s Disease: Neural Organization and Reorganization
Auteurs : Ines K. Goerendt ; Andrew D. Lawrence ; David J. BrooksSource :
- Cerebral Cortex [ 1047-3211 ] ; 2004-01.
Abstract
It has been suggested that motivational processes mediated by dopaminergic neural systems may be relatively spared in Parkinson’s disease (PD) and activation of these pathways may be of therapeutic relevance. To investigate the behavioural and neural correlates of motivation in unmedicated PD patients, we used H215O positron emission tomography to measure brain activation patterns related to the processing of monetary rewards of different magnitudes during a spatial search task in PD patients withdrawn from medication, and age-matched healthy controls. Both groups showed increased search efficiency with increasing reward, but demonstrated different patterns of neuronal activation. In healthy controls activity in prefrontal and rhinal cortices, and thalamic activity correlated with reward magnitude. In contrast, activity in the cerebellar vermis in PD patients increased with increasing reward magnitude, suggesting it was sensitive to motivational state. We interpret these relative increases in cerebellar activation as evidence for the presence of compensatory neural mechanisms in unmedicated PD patients.
Url:
DOI: 10.1093/cercor/bhg105
Affiliations:
Links toward previous steps (curation, corpus...)
Le document en format XML
<record><TEI wicri:istexFullTextTei="biblStruct"><teiHeader><fileDesc><titleStmt><title xml:lang="en">Reward Processing in Health and Parkinson’s Disease: Neural Organization and Reorganization</title><author><name sortKey="Goerendt, Ines K" sort="Goerendt, Ines K" uniqKey="Goerendt I" first="Ines K." last="Goerendt">Ines K. Goerendt</name></author><author><name sortKey="Lawrence, Andrew D" sort="Lawrence, Andrew D" uniqKey="Lawrence A" first="Andrew D." last="Lawrence">Andrew D. Lawrence</name></author><author><name sortKey="Brooks, David J" sort="Brooks, David J" uniqKey="Brooks D" first="David J." last="Brooks">David J. Brooks</name></author></titleStmt><publicationStmt><idno type="wicri:source">ISTEX</idno><idno type="RBID">ISTEX:9992855FC7773B91190D6DC6DAF3935EB07398FD</idno><date when="2004" year="2004">2004</date><idno type="doi">10.1093/cercor/bhg105</idno><idno type="url">https://api.istex.fr/document/9992855FC7773B91190D6DC6DAF3935EB07398FD/fulltext/pdf</idno><idno type="wicri:Area/Main/Corpus">001A34</idno><idno type="wicri:Area/Main/Curation">001777</idno><idno type="wicri:Area/Main/Exploration">001581</idno></publicationStmt><sourceDesc><biblStruct><analytic><title level="a" type="main" xml:lang="en">Reward Processing in Health and Parkinson’s Disease: Neural Organization and Reorganization</title><author><name sortKey="Goerendt, Ines K" sort="Goerendt, Ines K" uniqKey="Goerendt I" first="Ines K." last="Goerendt">Ines K. Goerendt</name><affiliation><wicri:noCountry code="syntax">???</wicri:noCountry></affiliation></author><author><name sortKey="Lawrence, Andrew D" sort="Lawrence, Andrew D" uniqKey="Lawrence A" first="Andrew D." last="Lawrence">Andrew D. Lawrence</name><affiliation><wicri:noCountry code="syntax">???</wicri:noCountry></affiliation><affiliation><wicri:noCountry code="syntax">???</wicri:noCountry></affiliation></author><author><name sortKey="Brooks, David J" sort="Brooks, David J" uniqKey="Brooks D" first="David J." last="Brooks">David J. Brooks</name><affiliation><wicri:noCountry code="syntax">???</wicri:noCountry></affiliation></author></analytic><monogr></monogr><series><title level="j">Cerebral Cortex</title><title level="j" type="abbrev">Cereb. Cortex</title><idno type="ISSN">1047-3211</idno><idno type="eISSN">1460-2199</idno><imprint><publisher>Oxford University Press</publisher><date type="published" when="2004-01">2004-01</date><biblScope unit="volume">14</biblScope><biblScope unit="issue">1</biblScope><biblScope unit="page" from="73">73</biblScope><biblScope unit="page" to="80">80</biblScope></imprint><idno type="ISSN">1047-3211</idno></series><idno type="istex">9992855FC7773B91190D6DC6DAF3935EB07398FD</idno><idno type="DOI">10.1093/cercor/bhg105</idno><idno type="local">bhg105</idno></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">1047-3211</idno></seriesStmt></fileDesc><profileDesc><textClass></textClass><langUsage><language ident="en">en</language></langUsage></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">It has been suggested that motivational processes mediated by dopaminergic neural systems may be relatively spared in Parkinson’s disease (PD) and activation of these pathways may be of therapeutic relevance. To investigate the behavioural and neural correlates of motivation in unmedicated PD patients, we used H215O positron emission tomography to measure brain activation patterns related to the processing of monetary rewards of different magnitudes during a spatial search task in PD patients withdrawn from medication, and age-matched healthy controls. Both groups showed increased search efficiency with increasing reward, but demonstrated different patterns of neuronal activation. In healthy controls activity in prefrontal and rhinal cortices, and thalamic activity correlated with reward magnitude. In contrast, activity in the cerebellar vermis in PD patients increased with increasing reward magnitude, suggesting it was sensitive to motivational state. We interpret these relative increases in cerebellar activation as evidence for the presence of compensatory neural mechanisms in unmedicated PD patients.</div></front></TEI><affiliations><list></list><tree><noCountry><name sortKey="Brooks, David J" sort="Brooks, David J" uniqKey="Brooks D" first="David J." last="Brooks">David J. Brooks</name><name sortKey="Goerendt, Ines K" sort="Goerendt, Ines K" uniqKey="Goerendt I" first="Ines K." last="Goerendt">Ines K. Goerendt</name><name sortKey="Lawrence, Andrew D" sort="Lawrence, Andrew D" uniqKey="Lawrence A" first="Andrew D." last="Lawrence">Andrew D. Lawrence</name></noCountry></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
EXPLOR_STEP=$WICRI_ROOT/Wicri/Sante/explor/ParkinsonV1/Data/Main/Exploration
HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 001581 | SxmlIndent | more
Ou
HfdSelect -h $EXPLOR_AREA/Data/Main/Exploration/biblio.hfd -nk 001581 | SxmlIndent | more
Pour mettre un lien sur cette page dans le réseau Wicri
{{Explor lien
|wiki= Wicri/Sante
|area= ParkinsonV1
|flux= Main
|étape= Exploration
|type= RBID
|clé= ISTEX:9992855FC7773B91190D6DC6DAF3935EB07398FD
|texte= Reward Processing in Health and Parkinson’s Disease: Neural Organization and Reorganization
}}
| This area was generated with Dilib version V0.6.23. |  |